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Article

Clinicopathological features of breast cancer in Ukrainian women with BRCA1 c.181T>G (p.Cys61Gly) variant: a case series.

Frontiers in endocrinology - 1 Jan 2026

Kitsera Nataliya, Shparyk Yaroslav, Tril Orest, Protsko Ihor, Duda Ivanna, Oleksyak Olha, Hrynkiv Andrii, Dovhanyk Irena, Hrytsai Iryna, Tril Iryna, Makukh Halyna, Kruhlykova Alina, Kozakov Denys, Livshun Sofiia, Kobyliak Nazarii, Sobechko Solomiia, Oliyarnyk Myroslava, Sulaieva Oksana

Abstract excerpt

Introduction: BRCA1 c.181T>G (p.Cys61Gly) is a pathogenic founder genetic variant prevalent in Central and Eastern Europe. The data on its clinicopathological manifestations in Ukrainian patients remain limited. Aim: This study aimed to characterize clinical presentation, tumor biology, and family history in Ukrainian women with BRCA1 c.181T>G variant. Materials and methods: We conducted a single-centre case...

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Identifiers

PMID: 42453505
DOI: 10.3389/fendo.2026.1859939
PMCID: PMC13364604

Genes

BRCA1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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