Contribution of BRCA1 5382insC mutation to triplene-gative and luminal types of breast cancer in Ukraine.

doi:10.1007/s10549-022-06692-3

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Contribution of BRCA1 5382insC mutation to triplene-gative and luminal types of breast cancer in Ukraine.

Breast cancer research and treatment - 1 Oct 2022

Samusieva Anastasiia, Serga Svitlana, Klymenko Sergiy, Rybchenko Lyudmila, Klimuk Bohdana, Zakhartseva Liubov, Gorovenko Natalia, Lobanova Olga, Rossokha Zoia, Fishchuk Liliia, Levkovich Nataliia, Medvedieva Nataliia, Popova Olena, Cheshuk Valeriy, Inomistova Mariia, Khranovska Natalia, Skachkova Oksana, Michailovich Yurii, Ponomarova Olga, Kozeretska Iryna

Abstract excerpt

PURPOSE: The gene BRCA1 plays a key role in DNA repair in breast and ovarian cell lines and this is considered one of target tumor suppressor genes in same line of cancers. The 5382insC mutation is among the most frequently detected in patients (Eastern Europe) with triple-negative breast cancer (TNBC). In Ukraine, there is not enough awareness of necessity to test patients with TNBC for BRCA1 mutations. That is...

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PMID: 35930098
DOI: 10.1007/s10549-022-06692-3

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