Article
High frequency and allele-specific differences of BRCA1 founder mutations in breast cancer and ovarian cancer patients from Belarus.
Clinical genetics - 1 Oct 2010
Bogdanova N V, Antonenkova N N, Rogov Y I, Karstens J H, Hillemanns P, Dörk T
Abstract excerpt
Breast cancer and ovarian cancer are common malignancies in Belarus accounting for about 3500 and 800 new cases per year, respectively. For breast cancer, the rates and age of onset appear to vary significantly in regions differentially affected by the Chernobyl accident. We assessed the frequency and distribution of three BRCA1 founder mutations 5382insC, 4153delA and Cys61Gly in two hospital-based series of...
Topics
- Age of Onset
- Alleles
- Breast Neoplasms
- Chernobyl Nuclear Accident
- DNA Mutational Analysis
- Environmental Exposure
- Female
- Founder Effect
- Gene Frequency
- Genes, BRCA1
- Genetic Association Studies