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Molecular characteristics and prognostic insights into BRCA-associated breast cancer in Kazakhstan.

Scientific reports - 17 Jan 2026

Samigatova Ainur, Altaeva Nursulu, Suleimenov Yerlan, Sibiryakov Petr, Zhabagin Kuantkan, Zhakypbekkyzy Zhanar, Seksenbayev Bakhytzhan, Yoshihiro Noso, Tsigengagel Oxana

Abstract excerpt

Breast cancer remains the leading cause of cancer morbidity and mortality among women worldwide. Approximately 5-10% of cases involve pathogenic BRCA1/2 variants, typically associated with early-onset, aggressive disease. This study aimed to determine the frequency and spectrum of BRCA1/2 mutations among Kazakhstani breast cancer patients and to analyze their associations with clinicopathological features and...

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Identifiers

PMID: 41547905
DOI: 10.1038/s41598-026-36086-0
PMCID: PMC12891505

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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