Article
Integrated Histopathologic and Targeted Genomic Characterization of Gastric Adenocarcinomas with Yolk Sac Tumor Differentiation.
International journal of molecular sciences - 26 Jun 2026
Di Mauro Annabella, Rega Rosalia Anna, Sorrentino Rosalinda, Falanga Anna, Leongito Maddalena, Albino Vittorio, Belli Andrea, D'Arbitrio Imma, Simonelli Saverio, Cecio Rossella De, Tafuto Salvatore, Nasti Guglielmo, Ottaiano Alessandro, Tatangelo Fabiana
Abstract excerpt
Gastric adenocarcinomas with yolk sac tumor (YST) differentiation represent an exceptionally rare and poorly understood phenotype, characterized by the emergence of extraembryonic features within an epithelial malignancy. Their histogenesis remains debated, with increasing evidence supporting somatic lineage plasticity rather than germ cell origin. Here, we performed an integrated histopathologic and genomic...
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