Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.

doi:10.1038/s41467-018-04179-8

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Article

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.

Nature communications - 3 May 2018

Oh Sang Cheul, Sohn Bo Hwa, Cheong Jae-Ho, Kim Sang-Bae, Lee Jae Eun, Park Ki Cheong, Lee Sang Ho, Park Jong-Lyul, Park Yun-Yong, Lee Hyun-Sung, Jang Hee-Jin, Park Eun Sung, Kim Sang-Cheol, Heo Jeonghoon, Chu In-Sun, Jang You-Jin, Mok Young-Jae, Jung WonKyung, Kim Baek-Hui, Kim Aeree, Cho Jae Yong, Lim Jae Yun, Hayashi Yuki, Song Shumei, Elimova Elena, Estralla Jeannelyn S, Lee Jeffrey H, Bhutani Manoop S, Lu Yiling, Liu Wenbin, Lee Jeeyun, Kang Won Ki, Kim Sung, Noh Sung Hoon, Mills Gordon B, Kim Seon-Young, Ajani Jaffer A, Lee Ju-Seog

Abstract excerpt

Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low...

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PMID: 29725014
DOI: 10.1038/s41467-018-04179-8
PMCID: PMC5934392

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