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Molecular profiling of hepatoid adenocarcinoma and adenocarcinoma with enteroblastic differentiation.

Surgical oncology - 1 Feb 2026

Matsumoto Yosuke, Hatakeyama Keiichi, Terashima Masanori, Nagashima Takeshi, Urakami Kenichi, Shimoda Tadakazu, Sugino Takashi, Bando Etsuro, Yamashita Hiroharu, Okamura Yukiyasu, Yamaguchi Ken

Abstract excerpt

Hepatoid adenocarcinoma (HAD) and adenocarcinoma with enteroblastic differentiation (ACED) are rare gastric cancer types that produce alpha-fetoprotein (AFP) that morphologically resembles the liver or fetal organ. This study investigated the molecular profiling of HAD and ACED compared with common-type gastric adenocarcinoma (CGA). This study enrolled 496 patients with gastric adenocarcinoma who underwent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41232140
DOI: 10.1016/j.suronc.2025.102325

Genes

TP53
CGA
HMGA2
IGF2BP1
LIN28B
AFP
APOB
CREBBP
CSMD3
DROSHA
FAT3
GPC3
LRP1B
PASK
SALL4
STK40
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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