A Phenotype-Embedded Mapper Framework Links Microbiome-Metabolome Interaction Modules to Colorectal Cancer.

Abstract excerpt

Integrative analysis of the gut microbiome and metabolome can help characterize colorectal cancer (CRC)-associated molecular changes that are difficult to resolve from either omics layer alone. However, microbiome-metabolome data are high-dimensional, heterogeneous, and often contain nonlinear or locally confined associations that may be obscured by global linear models. Here, we propose a phenotype-guided...

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