Differential Correlations Informed Metabolite Set Enrichment Analysis to Decipher Metabolic Heterogeneity of Disease.

doi:10.1021/acs.analchem.3c02246

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Article

Differential Correlations Informed Metabolite Set Enrichment Analysis to Decipher Metabolic Heterogeneity of Disease.

Analytical chemistry - 22 Aug 2023

Lin Genjin, Dong Liheng, Cheng Kian-Kai, Xu Xiangnan, Wang Yongpei, Deng Lingli, Raftery Daniel, Dong Jiyang

Abstract excerpt

Metabolic pathways are regarded as functional and basic components of the biological system. In metabolomics, metabolite set enrichment analysis (MSEA) is often used to identify the altered metabolic pathways (metabolite sets) associated with phenotypes of interest (POI), e.g., disease. However, in most studies, MSEA suffers from the limitation of low metabolite coverage. Random walk (RW)-based algorithms can be...

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PMID: 37557184
DOI: 10.1021/acs.analchem.3c02246

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