Conditional dependency of oncogenic KRAS in driving ketone body catabolism and pancreatic cancer growth.

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy driven predominantly by oncogenic KRAS mutations, which enforce extensive metabolic reprogramming to support tumor progression. Although ketone body catabolism has emerged as a critical metabolic adaptation in PDAC, the signaling mechanisms that link mutant KRAS to the ketolytic machinery remain largely unexplored. Here, we identify a...

Topics

• Proto-Oncogene Proteins p21(ras)
• Humans
• Pancreatic Neoplasms
• Animals
• Ketone Bodies
• Mice