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Article

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis

19 Nov 2018

Abstract excerpt

Oncogenic KRAS is the key driver of pancreatic ductal adenocarcinoma (PDAC). We previously described a role for KRAS in PDAC tumor maintenance through rewiring of cellular metabolism to support proliferation. Understanding the details of this metabolic reprogramming in human PDAC may provide novel therapeutic opportunities. Here we show that the dependence on oncogenic KRAS correlates with specific metabolic...

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PMID: 30470748
DOI: 10.1038/s41467-018-07472-8

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