Coevolution of the broad-host-range bacteriophage EscoHU1 and host bacteria: Enhanced suppression of Escherichia coli O157:H7 and Salmonella enterica through adaptation of EscoHU1 to host bacteria.

Abstract excerpt

Shiga toxin-producing Escherichia coli and Salmonella enterica are major foodborne pathogens worldwide. In this study, we co-cultured the broad-host-range bacteriophage (phage) EscoHU1 with its bacterial hosts (E. coli O157:H7 and S. enterica serovar Typhimurium) and isolated mutant phages and bacteria. The isolated bacteria acquired resistance to EscoHU1 owing to impaired EscoHU1 adsorption. Further genomic...

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