Article
Germline whole-exome sequencing identifies CTNND1 as a candidate gene for hereditary gastric cancer in a large Brazilian cohort.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Sept 2026
de Souza Deivid Calebe, Buranello Thaliane, Neto Dario Tenorio Tavares, Pisani Janina Pontes, Ribeiro Giovanna Napolitano Pereira, Olandoski Marcia, Schlesinger David, Kitajima João Paulo, Viana Danilo Vilela, Achatz Maria Isabel
Abstract excerpt
BACKGROUND: Gastric cancer is the fifth most commonly diagnosed cancer. Although 10% of cases show familial clustering, a monogenic hereditary cause is rarely observed. Little is known about the molecular profile of familial gastric cancer cases in Brazil. Thus, we aimed to characterize the germline genomic profile of patients with potentially hereditary gastric cancer in the Brazilian population. METHODS: DNA...
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