Article

BRCA2-deficiency Causes Global Transcriptomic Alterations in Endothelial Cells

2025-09-17

Abstract excerpt

This study aims to explore the alterations in gene expression following BRCA2 loss in endothelial cells and to investigate the potential contribution of BRCA2 in regulating the endothelial protein-coding transcriptome. Cultured human umbilical vein endothelial cells (HUVECs) were transfected with siBRCA2 or non-targeting scrambled RNA as control. Total RNA was extracted and used for RNA sequencing following puri...

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Literature Corpus work: 7e711478-22e6-5fc3-adc4-10103f7c88cc
DOI: 10.1101/2025.09.14.676113

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