Article
Genome-wide association studies of missing metabolite measures from two population-based studies.
Genome biology - 10 Jul 2026
Faquih Tariq O, Imtiaz Mohammed Aslam, Talevi Valentina, Landstra Elvire N, van Hylckama Vlieg Astrid, Li-Gao Ruifang, Rosendaal Frits R, Noordam Raymond, van Heemst Diana, Mook-Kanamori Dennis O, Breteler Monique M B, Aziz N Ahmad, van Dijk Ko Willems
Abstract excerpt
BACKGROUND: Metabolomic analyses are increasingly applied in both etiological and predictive research, but frequently report missing values, which are then either imputed or removed from the analyses, and not examined as true missingness due to altered metabolism. We hypothesized that interindividual genetic variation may account for part of this missingness. RESULTS: We perform a logistic GWAS of metabolite...
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