Article
A multivariant recall-by-genotype study of the metabolomic signature of BMI.
Obesity (Silver Spring, Md.) - 1 Jun 2022
Fang Si, Wade Kaitlin H, Hughes David A, Fitzgibbon Sophie, Yip Vikki, Timpson Nicholas J, Corbin Laura J
Abstract excerpt
OBJECTIVE: This study estimated the effect of BMI on circulating metabolites in young adults using a recall-by-genotype study design. METHODS: A recall-by-genotype study was implemented in the Avon Longitudinal Study of Parents and Children. Samples from 756 participants were selected for untargeted metabolomics analysis based on low versus high genetic liability for higher BMI defined by a genetic risk score...
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