Article
A genome-wide association study of neonatal metabolites.
Cell genomics - 9 Oct 2024
He Quanze, Liu Hankui, Lu Lu, Zhang Qin, Wang Qi, Wang Benjing, Wu Xiaojuan, Guan Liping, Mao Jun, Xue Ying, Zhang Chunhua, Cao Xinye, He Yuxing, Peng Xiangwen, Peng Huanhuan, Zhao Kangrong, Li Hong, Jin Xin, Zhao Lijian, Zhang Jianguo, Wang Ting
Abstract excerpt
Genetic factors significantly influence the concentration of metabolites in adults. Nevertheless, the genetic influence on neonatal metabolites remains uncertain. To bridge this gap, we employed genotype imputation techniques on large-scale low-pass genome data obtained from non-invasive prenatal testing. Subsequently, we conducted association studies on a total of 75 metabolic components in neonates. The study...
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