Article
Sample size calculation in metabolic phenotyping studies.
Briefings in bioinformatics - 1 Sept 2015
Billoir Elise, Navratil Vincent, Blaise Benjamin J
Abstract excerpt
The number of samples needed to identify significant effects is a key question in biomedical studies, with consequences on experimental designs, costs and potential discoveries. In metabolic phenotyping studies, sample size determination remains a complex step. This is due particularly to the multiple hypothesis-testing framework and the top-down hypothesis-free approach, with no a priori known metabolic target....
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