Membrane repair of human skeletal muscle cells requires Annexin-A5.

doi:10.1016/j.bbamcr.2016.06.003

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Article

Membrane repair of human skeletal muscle cells requires Annexin-A5.

Biochimica et biophysica acta - 1 Sept 2016

Carmeille Romain, Bouvet Flora, Tan Sisareuth, Croissant Coralie, Gounou Céline, Mamchaoui Kamel, Mouly Vincent, Brisson Alain R, Bouter Anthony

Abstract excerpt

Defect in membrane repair contributes to the development of limb girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy. In healthy skeletal muscle, unraveling membrane repair mechanisms requires to establish an exhaustive list of the components of the resealing machinery. Here we show that human myotubes rendered deficient for Annexin-A5 (AnxA5) suffer from a severe defect in membrane resealing. This...

Topics

Adult
Annexin A5
Cell Line
Cell Membrane
Dysferlin
Extracellular Space
Humans
Lasers
Lipid Bilayers
Membrane Proteins
Muscle Fibers, Skeletal
Muscle Proteins
Muscular Dystrophies, Limb-Girdle
Mutation

Source

Open in PubMed

Identifiers

PMID: 27286750
DOI: 10.1016/j.bbamcr.2016.06.003

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Myoblasts

Recombinant Proteins

Sarcolemma

Subcellular Fractions