Article

Defective Trafficking of Annexins to the Site of Injury in ANO5-Knockout Muscle Fibers

2020-05-24

Abstract excerpt

Mutations in ANO5 ( TMEM16E ) cause limb-girdle muscular dystrophy R12 (limb-girdle muscular dystrophy type 2L). Recent evidence implicates defective plasma membrane repair as a likely mechanism for the disorder. Here, we probe the ANO5-dependency of the membrane repair pathway using a laser wounding assay in Ano5 knockout mouse muscle fibers. Wounded myofibers from Ano5 knockout mice exhibit delayed membrane...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b3d214c-b6c7-5353-bd3c-85c79db4ff9d
DOI: 10.1101/2020.05.22.110825

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defective Trafficking of Annexins to the Site of Injury in ANO5-Knockout Muscle FibersDOI 10.1101/2020.05.22.110825Read

ANO5 ensures trafficking of annexins in wounded myofibers.Semantic proximity Read

Defective membrane fusion and repair in Anoctamin5-deficient muscular dystrophy.Semantic proximity Read

Membrane repair of human skeletal muscle cells requires Annexin-A5.Semantic proximity Read

Recombinant annexin A6 promotes membrane repair and protects against muscle injurySemantic proximity Read

Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle CellsSemantic proximity Read

Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair.Semantic proximity Read

Duchenne muscular dystrophy is driven by defective membrane repair and annexin-A2 dysregulation in skeletal muscleSemantic proximity Read

Anoctamin 5 Knockout Mouse Model Recapitulates LGMD2L Muscle Pathology and Offers Insight Into in vivo Functional Deficits.Semantic proximity Read

Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.Semantic proximity Read

Sarcolemmal repair is a slow process and includes EHD2.Semantic proximity Read

Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption.Semantic proximity Read

Muscle Cells Fix Breaches by Orchestrating a Membrane Repair Ballet.Semantic proximity Read