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Article

Personalizing Breast Cancer Screening Based on Polygenic Risk and Family History.

Journal of the National Cancer Institute - 6 Apr 2021

van den Broek Jeroen J, Schechter Clyde B, van Ravesteyn Nicolien T, Janssens A Cecile J W, Wolfson Michael C, Trentham-Dietz Amy, Simard Jacques, Easton Douglas F, Mandelblatt Jeanne S, Kraft Peter, de Koning Harry J

Abstract excerpt

BACKGROUND: We assessed the clinical utility of a first-degree breast cancer family history and polygenic risk score (PRS) to inform screening decisions among women aged 30-50 years. METHODS: Two established breast cancer models evaluated digital mammography screening strategies in the 1985 US birth cohort by risk groups defined by family history and PRS based on 313 single nucleotide polymorphisms. Strategies...

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Source

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Identifiers

PMID: 32853342
DOI: 10.1093/jnci/djaa127
PMCID: PMC8599807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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