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Integrative functional genomics maps synaptic and developmental-regulatory autism risk-gene sets across human cortex.

Functional & integrative genomics - 8 Jul 2026

Lian Aojie, Wang Qiong, He Mei, Zhang Hong

Abstract excerpt

Autism spectrum disorder (ASD) risk genes converge on synaptic and developmental regulatory biology, but it remains unclear whether fixed risk-gene sets retain the same functional meaning across prenatal and adult cortical contexts. We analyzed predefined ASD risk-gene sets across BrainSpan developmental transcriptomics, three adult cortical bulk cohorts, fetal and adult single-cell resources, composition-aware...

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PMID: 42418076
DOI: 10.1007/s10142-026-01971-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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