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Article

A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals.

PLoS genetics - 1 Aug 2020

Örd Tiit, Puurand Tarmo, Örd Daima, Annilo Tarmo, Möls Märt, Remm Maido, Örd Tõnis

Abstract excerpt

Tribbles homolog 3 (TRIB3) is pseudokinase involved in intracellular regulatory processes and has been implicated in several diseases. In this article, we report that human TRIB3 promoter contains a 33-bp variable number tandem repeat (VNTR) and characterize the heterogeneity and function of this genetic element. Analysis of human populations around the world uncovered the existence of alleles ranging from 1 to 5...

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Identifiers

PMID: 32745133
DOI: 10.1371/journal.pgen.1008981
PMCID: PMC7425993

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