Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accelerated Biological Aging Increases the Risk of Head and Neck Cancer: Insights From Genetic Instruments of Epigenetic Clocks.

Molecular carcinogenesis - 1 Sept 2026

Wang Jiaqi, Deng Jie, Xu Yifan, Tsai Chia-Wen, Chang Wen-Shin, Deng Yang, Huang Maosheng, Bau Da-Tian, Li Guojun, Gu Jian

Abstract excerpt

Epigenetic clocks are robust biomarkers of biological aging and have been associated with cancer susceptibility. However, the relationship between genetically predicted epigenetic age acceleration and head and neck cancer risk remains unclear. Using a large case-control study of 2189 head and neck squamous cell carcinoma (HNSCC) cases and 2189 age- and sex-matched controls, we investigated the associations...

Topics

Join the communities discussing this publication.

Aging
Case-Control Studies
Epigenesis, Genetic
Genetic Risk Score
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Head and Neck Neoplasms

Mendelian Randomization Analysis

Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 42391445
DOI: 10.1002/mc.70144
PMCID: PMC13466172

Genes

PBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accelerated Biological Aging Increases the Risk of Head and Neck Cancer: Insights From Genetic Instruments of Epigenetic Clocks.PMID 42391445Read ↗

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.Semantic proximity Read ↗

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancerSemantic proximity Read ↗

Epigenetic Clocks: In Aging-Related and Complex DiseasesSemantic proximity Read ↗

Specific epigenetic age acceleration measures are associated with oral health outcomes in U.S. adultsSemantic proximity Read ↗

DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility.Semantic proximity Read ↗

A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration.Semantic proximity Read ↗

A meta-analysis of genome-wide association studies of epigenetic age acceleration.Semantic proximity Read ↗

Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk.Semantic proximity Read ↗

Menopause accelerates biological aging.Semantic proximity Read ↗

Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohortSemantic proximity Read ↗

Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms.Semantic proximity Read ↗

Metabolic profiling of DNA methylation age acceleration, associations with hearing loss and interaction with genetic susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.