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Metabolic profiling of DNA methylation age acceleration, associations with hearing loss and interaction with genetic susceptibility.

Free radical biology & medicine - 1 Sept 2026

He Yaling, Niu Rundong, Diao Tingyue, Huang Kun, Huang Rongchuan, Wang Yufei, Zhang Rui, Wang Zhichao, Yang Liangle, He Meian, Kong Weijia, Zhang Xiaomin

Abstract excerpt

Limited studies have examined the association between DNA methylation age acceleration (DNAm AA) and hearing loss (HL). We aimed to assess whether plasma metabolite alterations are associated with the DNAm AA-HL link and explore the potential modifying effect of polygenic risk score (PRS). A total of 2068 individuals aged 65.7 years from the Dongfeng-Tongji cohort in 2013 were included. Hearing threshold was...

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Aged
Aging
DNA Methylation
Epigenesis, Genetic
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42242594
DOI: 10.1016/j.freeradbiomed.2026.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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