Article
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.
eLife - 29 Mar 2022
Morales Berstein Fernanda, McCartney Daniel L, Lu Ake T, Tsilidis Konstantinos K, Bouras Emmanouil, Haycock Philip, Burrows Kimberley, Phipps Amanda I, Buchanan Daniel D, Cheng Iona, Martin Richard M, Davey Smith George, Relton Caroline L, Horvath Steve, Marioni Riccardo E, Richardson Tom G, Richmond Rebecca C
Abstract excerpt
Background: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker. Methods: We conducted a two-sample Mendelian randomization (MR) study to examine the genetically predicted effects of epigenetic age acceleration as measured by HannumAge (nine single-nucleotide...
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