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Article

Integrated analysis of chromatin accessibility and transcriptome profiles in granulosa cells of sheep with different FecB genotypes.

BMC genomics - 1 Jul 2026

Liu Qing, Hou Senxuan, Liu Kai, Chi Runqing, Pu Xiufen, Xiang Yuping, Gu Shiyu, Liu Yufang, Chu Mingxing

Abstract excerpt

BMPR1B is the major gene regulating ovine fertility, wherein the A746G coding mutation (the FecB mutation) has been shown to markedly increase ovulation rate and lambing number. Granulosa cells (GCs) provide essential support for follicular development and oocyte maturation, directly influencing reproductive performance. However, the epigenetic mechanisms by which FecB genotypes regulate GCs function via...

Read the complete abstract on PubMed

Topics

Animals
Female
Granulosa Cells
Chromatin
Sheep
Genotype
Transcriptome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Profiling

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42387369
DOI: 10.1186/s12864-026-13116-9
PMCID: PMC13591929

Genes

CYP2R1
HK2
BMPR1B
FBN1
PTGFR
TFAP2A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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