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Impact of FecB Mutation on Ovarian DNA Methylome in Small-Tail Han Sheep.

Genes - 12 Jan 2023

Xie Lingli, Miao Xiangyang, Luo Qingmiao, Zhao Huijing, Qin Xiaoyu

Abstract excerpt

Booroola fecundity (FecB) gene, a mutant of bone morphogenetic protein 1B (BMPR-1B) that was discovered in Booroola Merino, was the first prolificacy gene identified in sheep related to increased ovulation rate and litter size. The mechanism of FecB impact on reproduction is unclear. METHODS: In this study, adult Han ewes with homozygous FecB(B)/FecB(B) mutations (Han BB group) and ewes with FecB(+)/FecB(+)...

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PMID: 36672944
DOI: 10.3390/genes14010203
PMCID: PMC9859159

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