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Article

Single-cell RNA-seq reveals the effects of the FecB mutation on the transcriptome profile in ovine cumulus cells.

Scientific reports - 7 Jun 2024

Guo Xiaofei, Fang Yi, Liang Rong, Wang Xiangyu, Zhang Jinlong, Dong Chunxiao, Wang Biao, Liu Yu, Chu Mingxing, Zhang Xiaoshen, Zhong Rongzhen

Abstract excerpt

Genetic variations in the ovine ovulation rate, which are associated with the FecB mutation, provide useful models by which to explore the mechanisms regulating the development of mammalian antral follicles. In order to study the effects of the FecB mutation on cumulus cell differentiation, preovulatory follicles were aspirated and cumulus cells were isolated from three FecB genotypes (homozygous, heterozygous...

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Identifiers

PMID: 38849498
DOI: 10.1038/s41598-024-64001-y
PMCID: PMC11161497

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