Influence of inflammatory and reninangiotensin system gene polymorphisms ACE2 rs2285666, IL1A rs1800587, and TNF rs1800629 on COVID-19 severity and the persistence of symptoms in the post-COVID-19 phase: a cross-sectional study.

doi:10.31744/einstein_journal/2026AO1503

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Article

Influence of inflammatory and reninangiotensin system gene polymorphisms ACE2 rs2285666, IL1A rs1800587, and TNF rs1800629 on COVID-19 severity and the persistence of symptoms in the post-COVID-19 phase: a cross-sectional study.

Einstein (Sao Paulo, Brazil) - 1 Jan 2026

Daudt-Lemos Matheus, Oliveira Evelyn Maciel de, Ramos-Silva Alice, Rosário Natalia Fonseca, Gonçalves Thays Araújo, Nascimento Camila de Melo Carvalho, Valle Amanda Mendes do, André Lialyz Soares Pereira, Aguiar-Alves Fabio, Matos Jorge Paulo Strogoff de, Lugon Jocemir Ronaldo, Almeida Jorge Reis, Medeiros Thalia, Kohlrausch Fabiana Barzotto, Silva Andrea Alice

Abstract excerpt

OBJECTIVE: We evaluated the influence of single-nucleotide polymorphisms in cytokine, renin-angiotensin-aldosterone system, and uromodulin genes on COVID-19 severity and the persistence of symptoms in the post-COVID phase. METHODS: Two cross-sectional cohort studies were conducted: a retrospective cohort (cohort 1) from early phase of the pandemic and a prospective cohort (cohort 2) including patients with...

Topics

Humans
Middle Aged
Male
Female
Cross-Sectional Studies
Polymorphism, Single Nucleotide
Tumor Necrosis Factor-alpha
COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Severity of Illness Index

Angiotensin-Converting Enzyme 2

Renin-Angiotensin System

Interleukin-1alpha

Aged

Prospective Studies

Retrospective Studies

Adult

SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 42384984
DOI: 10.31744/einstein_journal/2026AO1503
PMCID: PMC13399304

Genes

TNF
ACE2
IL1A
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-42384984-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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