Article
Loss of O-antigen due to wbbL mutations is common and associated with increased mortality in Escherichia coli bloodstream infections.
Science advances - 3 Jul 2026
Tyson Kaleb J, Velez Amanda Z, Hanson Blake M, Jiang Jianping, Lu Kuan-Yi, Ruffin Felicia, Sutton Granger, Brinkac Lauren M, Clarke Thomas H, Tao Yazhong, Fouts Derrick E, Adams Mark D, Arias Cesar A, Khandelwal Sanjay, Fowler Vance G, Thaden Joshua T, Conlon Brian P, Parsons Joshua B
Abstract excerpt
Escherichia coli bloodstream infections are common and associated with high mortality. A key feature of E. coli is the lipopolysaccharide (LPS) O-antigen, which contributes to immune evasion during invasive infection. We analyzed serial isolates from patients with relapsed E. coli bacteremia and identified frequent disruption of O-antigen synthesis due to mutations in wbbL, resulting in a rough LPS phenotype....
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