Article
Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy.
PLoS pathogens - 1 Apr 2009
Fransen Floris, Heckenberg Sebastiaan G B, Hamstra Hendrik Jan, Feller Moniek, Boog Claire J P, van Putten Jos P M, van de Beek Diederik, van der Ende Arie, van der Ley Peter
Abstract excerpt
Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Lipopolysaccharide (LPS), a major component of the Gram-negative bacterial outer membrane, is sensed by mammalian cells through Toll-like receptor 4 (TLR4), resulting in activation of proinflammatory cytokine pathways. TLR4 recognizes the lipid A moiety of the LPS molecule, and the chemical composition of the lipid A determines...
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