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Article

Insights into the transmembrane helix associations of kit ligand by molecular dynamics simulation and TOXCAT.

Proteins - 1 Jul 2017

Chai Mengya, Liu Bo, Sun Fude, Wei Peng, Chen Peng, Xu Lida, Luo Shi-Zhong

Abstract excerpt

Kit ligand (KITL) plays important roles in cell proliferation, differentiation, and survival via interaction with its receptor Kit. The previous studies demonstrated that KITL formed a noncovalent homodimer through transmembrane (TM) domain; however, the undergoing mechanism of transmembrane association that determines KITL TM dimerization is still not clear. Herein, molecular dynamics (MD) simulation strategy...

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Identifiers

PMID: 28370370
DOI: 10.1002/prot.25297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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