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Article

Opportunities and challenges of dihydrodiol dehydrogenase expression in hepatocellular carcinoma.

Critical reviews in oncology/hematology - 1 Sept 2026

Kuang Yong, Hu Kai, Zhu Hongya, Lin Ruying, Wang Dehao, Huang Yuehan, Yuan Weijie, Chen Jingyao, Sun Yazhou, Feng Jiahao

Abstract excerpt

Hepatocellular carcinoma (HCC) is a prevalent global malignant tumor, which frequently exhibits a concomitant dysregulation of redox homeostasis and energy metabolism. TP53, a core tumor suppressor gene, can influence HCC progression by regulating mitochondrial homeostasis and ferroptosis. Abnormal Dihydrodiol dehydrogenase（DDH ）expression causes mitochondrial dysfunction, driving HCC malignant transformation and...

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Share to Carcinoma, Hepatocellular
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

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Source

Identifiers

PMID: 42379507
DOI: 10.1016/j.critrevonc.2026.105462

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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