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Integrating whole-genome bisulfite sequencing and TCGA data reveals methylation patterns associated with the MTHFR 677 C > T Variant.

Scientific reports - 29 Jun 2026

Zhang Guoping, Hou Juanjuan, Guo Mingliang, JiamingYan, Gao Xingzhe, Yang Run, Wang Zhenyun, Dong ZhiChun

Abstract excerpt

This study investigated the influence of the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism on bladder urothelial carcinoma (BLCA) using whole-genome bisulfite sequencing (WGBS) and The Cancer Genome Atlas (TCGA) data. The TT genotype was associated with reduced global DNA methylation, thereby altering the molecular landscape of BLCA. Differential methylation analysis identified three molecular...

Topics

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DNA Methylation
CD4 gene
Gene Expression Regulation, Neoplastic
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Urinary Bladder Neoplasms

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 42373686
DOI: 10.1038/s41598-026-54966-3
PMCID: PMC13315911

Genes

MTHFR
CD4
FGFR3
RASSF1
TRIM27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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