Platelet Proteome Links Metabolism to Reactivity in Essential Thrombocythemia.

doi:10.1016/j.mcpro.2026.101617

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Article

Platelet Proteome Links Metabolism to Reactivity in Essential Thrombocythemia.

Molecular & cellular proteomics : MCP - 1 Aug 2026

Guerrero-Carreño Xiomara, Smits Sanne, Esteban Lasso Alfonso, Samiotaki Martina, Calabuig-Navarro Virtu, Iborra Francisco José, Rantanen Frida, Álvarez-Larrán Alberto, Angona Figueras Anna, Bellosillo Beatriz, Sáez Marín Adolfo J, García-Gutiérrez Valentín, Dekkers Dick H W, Demmers Jeroen A A, Ferrer-Marín Francisca, Hernández-Boluda Juan Carlos, Matsakas Antonios, Benavente Cuesta Celina, Vandenberghe Peter, Papadopoulos Petros

Abstract excerpt

Essential thrombocythemia (ET) is a myeloproliferative neoplasm in which JAK2, CALR, and MPL mutations are associated with distinct clinical phenotypes. Here, we analyzed the platelet proteome of ET patients by MS, combined with functional assays, to investigate platelet activation. Compared with healthy controls, ET platelets showed altered abundance of mitochondrial and metabolic proteins, including reduced...

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