Article

Proteome analysis of platelets in Essential Thrombocythemia couples metabolism to platelet reactivity

2025-03-17

Abstract excerpt

Platelets are key players in hemostasis and thrombosis. Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) in which the JAK2 V617F, MPL W515K/L, and CALR mutations determine differences in clinical phenotype, in particular the thrombotic risk and the risk of myelofibrosis. Here, we examined the proteome of platelets in ET by mass spectrometry (MS) in combination with functional assays to gain in...

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Literature Corpus work: af5546a1-daf1-5e59-9b56-a4a43a5f82b8
DOI: 10.1101/2025.03.10.25323560

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