Article
Integrating DNA Mutations and RNA Expression of Cancer Driver Genes in Asian Rare Cancers: A Pan-Cancer Analysis.
JCO precision oncology - 1 Jun 2026
de Almeida Kathleen Yasmin, Imasa Marcelo Severino B, Voon Pei Jye, Soo Hoo Hwoei Fen, Chen Tom Wei-Wu, Yusak Suhana, Ramachandran Rangasamy, Abu Bakar Najihah, Chen Ming-Huang, Yatabe Yasushi, Nakamura Kenichi, Okuma Hitomi Sumiyoshi, Yonemori Kan
Abstract excerpt
PURPOSE: Rare cancers are molecularly heterogeneous and lack robust clinical evidence to guide treatment. Whether cancer driver gene expression is governed by tumor lineage or specific somatic alterations-and whether this distinction carries clinical relevance-remains poorly characterized, particularly in Asian populations. This study aimed to determine the relative contributions of tumor lineage and DNA...
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