Article
Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma.
Molecular cancer - 1 May 2025
Liu Bing, Tao Wei, Zhou Xuantong, Xu Li-Di, Luo Yanrui, Yang Xin, Min Qingjie, Huang Miao, Zhu Yuge, Cui Xinrun, Wang Yaqi, Gong Tongyang, Zhang Enli, Huang Yu S, Chen Weizhi, Yan Shi, Wu Nan
Abstract excerpt
INTRODUCTION: Early-stage poorly differentiated lung adenocarcinoma (LUAD) is plagued by a high risk of postoperative recurrence, and its prognostic heterogeneity complicates treatment and surveillance planning. We conducted this integrative multi-omics study to identify those patients with a truly high risk of adverse outcomes. METHODS: Whole-exome, RNA and whole methylome sequencing were carried out on 101...
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