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Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma

1 May 2025

Abstract excerpt

INTRODUCTION: Early-stage poorly differentiated lung adenocarcinoma (LUAD) is plagued by a high risk of postoperative recurrence, and its prognostic heterogeneity complicates treatment and surveillance planning. We conducted this integrative multi-omics study to identify those patients with a truly high risk of adverse outcomes. METHODS: Whole-exome, RNA and whole methylome sequencing were carried out on 101...

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PMID: 40312720
DOI: 10.1186/s12943-025-02333-7

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