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Article

Inferring genetic associations of programmed cell death genes with retinitis pigmentosa through multimodal Mendelian randomization.

Molecular medicine (Cambridge, Mass.) - 27 Jun 2026

Guo Nan, Peng Guang-Hua

Abstract excerpt

BACKGROUND: Retinitis pigmentosa (RP), a leading cause of inherited blindness, lacks effective treatment, necessitating the elucidation of its pathogenesis and identification of novel therapeutic targets. This study aimed to identify the genetic role of programmed cell death (PCD)-related genes in RP pathogenesis via an integrative multimodal framework. METHODS: We integrated summary-level data from genome-wide...

Read the complete abstract on PubMed

Topics

Retinitis Pigmentosa
Humans
Genome-Wide Association Study
Quantitative Trait Loci
Mendelian Randomization Analysis
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Apoptosis

Polymorphism, Single Nucleotide

Transcriptome

Phenotype

Gene Expression Profiling

Source

Open in PubMed Open full text

Identifiers

PMID: 42365225
DOI: 10.1186/s10020-026-01547-9
PMCID: PMC13579998

Genes

AIM2

Provenance

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