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The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery

6 Feb 2024

Abstract excerpt

BACKGROUND: Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In the pursuit of unraveling the intricate dynamics underlying this complex disease, mechanistic models emerge as a tool of proven efficiency rooted in systems biology, to elucidate the interplay between RP genes and their mechanisms. The integration of mechanistic models and...

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PMID: 38321543
DOI: 10.1186/s12967-024-04911-7

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