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Article

The Role of Programmed Cell Death-Related Genes in Asthma, Chronic Obstructive Pulmonary Disease, and Lung Function: A Multi-Omics Mendelian Randomization Study.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Ji Tanao, Lv Yue, Gu Jun

Abstract excerpt

Purpose: Programmed cell death (PCD) has been linked to asthma, chronic obstructive pulmonary disease (COPD) and lung function, but the underlying genetic determinants remain unclear. Patients and Methods: A comprehensive multi-omics analysis was conducted by integrating genome-wide association studies (GWAS) with methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein...

Topics

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Asthma
Forced Expiratory Volume
Lung
Mendelian Randomization Analysis
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 41788971
DOI: 10.2147/COPD.S561510
PMCID: PMC12958982

Genes

ERBB3
FGFR1
HSPA1B
IDUA
MAPK3
SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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