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Article

Mutant huntingtin is present in neuronal grafts in Huntington disease patients.

Annals of neurology - 1 Jul 2014

Cicchetti Francesca, Lacroix Steve, Cisbani Giulia, Vallières Nicolas, Saint-Pierre Martine, St-Amour Isabelle, Tolouei Ranna, Skepper Jeremy N, Hauser Robert A, Mantovani Diego, Barker Roger A, Freeman Thomas B

Abstract excerpt

OBJECTIVE: Huntington disease (HD) is caused by a genetically encoded pathological protein (mutant huntingtin [mHtt]), which is thought to exert its effects in a cell-autonomous manner. Here, we tested the hypothesis that mHtt is capable of spreading within cerebral tissue by examining genetically unrelated fetal neural allografts within the brains of patients with advancing HD. METHODS: The presence of mHtt...

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PMID: 24798518
DOI: 10.1002/ana.24174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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