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Genome-wide polygenic risk score for retinopathy of type 2 diabetes.

Human molecular genetics - 29 May 2021

Forrest Iain S, Chaudhary Kumardeep, Paranjpe Ishan, Vy Ha My T, Marquez-Luna Carla, Rocheleau Ghislain, Saha Aparna, Chan Lili, Van Vleck Tielman, Loos Ruth J F, Cho Judy, Pasquale Louis R, Nadkarni Girish N, Do Ron

Abstract excerpt

Diabetic retinopathy (DR) is a common consequence in type 2 diabetes (T2D) and a leading cause of blindness in working-age adults. Yet, its genetic predisposition is largely unknown. Here, we examined the polygenic architecture underlying DR by deriving and assessing a genome-wide polygenic risk score (PRS) for DR. We evaluated the PRS in 6079 individuals with T2D of European, Hispanic, African and other...

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Identifiers

PMID: 33704450
DOI: 10.1093/hmg/ddab067
PMCID: PMC8165647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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