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BRCA1/2 NGS Somatic Testing in Clinical Practice: A Short Report.

Genes - 28 Nov 2021

Pepe Francesco, Pisapia Pasquale, Russo Gianluca, Nacchio Mariantonia, Pallante Pierlorenzo, Vigliar Elena, De Angelis Carmine, Insabato Luigi, Bellevicine Claudio, De Placido Sabino, Troncone Giancarlo, Malapelle Umberto

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of all ovarian carcinomas. HGSOC harboring BRCA1/2 germline or somatic mutations are sensitive to the poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi). Therefore, detecting these mutations is crucial to identifying patients for PARPi-targeted treatment. In the clinical setting, next generation sequencing (NGS) has proven to be...

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Identifiers

PMID: 34946865
DOI: 10.3390/genes12121917
PMCID: PMC8702012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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