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Article

Predictive value of the polygenic risk score for developing epilepsy: a systematic review and meta-analysis.

Epilepsy & behavior : E&B - 1 Aug 2025

Kubota Takafumi, Ngadimon Irma Wati, Ohseto Hisashi, Viswanathan Sindhu, Ravat Parthvi, Acharya Mrinal Kumar, Kuroda Naoto, Konomatsu Kazutoshi, Obara Taku, Jin Kazutaka, Aoki Masashi, Nakasato Nobukazu

Abstract excerpt

PURPOSE: This study aimed to integrate the findings of previous studies to clarify the predictive value of the polygenic risk score (PRS) for epilepsy. METHODS: The MEDLINE, EMBASE, and CENTRAL databases were systematically searched for studies investigating PRS in epilepsy. Additionally, a meta-analysis was performed using random-effects models of studies that included PRS calculations using similar...

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Topics

Humans
Epilepsy
Multifactorial Inheritance
Genetic Predisposition to Disease
Predictive Value of Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Risk Score

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Identifiers

PMID: 40319673
DOI: 10.1016/j.yebeh.2025.110438

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