Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[CRISPR/Cas9-mediated knockout of the Soc gene in T4 bacteriophage and mutant construction].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 25 Jun 2026

Wang Bo, DU Chengquan, Gege Rile, Zhao Qihuan, Wang Hui, Li Baohui, Wang Jingjing, Mei Jingsi, Zhang Shujun, Bao Fuxiang

Abstract excerpt

To address the antigen display limitations of current vaccine carriers, we engineered the T4 bacteriophage into a high-capacity platform. The T4 bacteriophage has advantages such as structural stability, high loading capacity, and easy production. However, the presence of high-copy endogenous Soc protein on its capsid surface severely restricts the effective display of exogenous proteins. To overcome the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophage T4
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Gene Knockout Techniques

Share to Mutation

Source

Identifiers

PMID: 42343816
DOI: 10.13345/j.cjb.250870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[CRISPR/Cas9-mediated knockout of the Soc gene in T4 bacteriophage and mutant construction].PMID 42343816Read ↗

Advances in the T7 phage display system (Review).Semantic proximity Read ↗

A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineeringSemantic proximity Read ↗

SpyPhage: A Cell-Free TXTL Platform for Rapid Engineering of Targeted Phage TherapiesSemantic proximity Read ↗

Synthetic and Functional Engineering of Bacteriophages: Approaches for Tailored Bactericidal, Diagnostic, and Delivery PlatformsSemantic proximity Read ↗

Synthetic and Functional Engineering of Bacteriophages: Approaches for Tailored Bactericidal, Diagnostic, and Delivery PlatformsSemantic proximity Read ↗

Efficient synthesis of CRISPR-Cas13a-antimicrobial capsids against MRSA facilitated by silent mutation incorporation.Semantic proximity Read ↗

An <i>E. coli</i> -based platform for the production and assembly of anellovirus vectorsSemantic proximity Read ↗

Genomic investigation of lysogen formation and host lysis systems of the Salmonella temperate bacteriophage SPN9CC.Semantic proximity Read ↗

Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffoldSemantic proximity Read ↗

Tn5 Transposon-based Mutagenesis for Engineering Phage-resistant Strains of Escherichia coli BL21 (DE3).Semantic proximity Read ↗

Modification of T2 phage infectivity towardEscherichia coliO157:H7 via using CRISPR/Cas9Semantic proximity Read ↗

Engineering M13 for phage display.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.