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Article

A putative role for Mrx3 and Fmp10 in regulating yeast mitochondrial acyl-CoA thioesters.

Biochimica et biophysica acta. Molecular cell research - 1 Aug 2026

Costa-Lima Marcelo Mesa, Gomes Fernando, Damaceno Thaynara Roberta, Barros Mário H

Abstract excerpt

The hotdog-fold acyl-CoA thioesterases (ACOTs) are enzymes typically related to lipid metabolism and are widely spread across the tree of life, but many members of this group are poorly characterized. In this work, through in silico analyzes we identified the MICOS-associated mitochondrial proteins of unknown function Mrx3 and Fmp10 as two putative ACOTs in Saccharomyces cerevisiae with structural homology to the...

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PMID: 42341887
DOI: 10.1016/j.bbamcr.2026.120178

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