Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Late-stage dedifferentiation and epigenetic memory of cancer stem cells in hepatocellular carcinoma.

Journal of translational medicine - 23 Jun 2026

Hu Yi-Kai, Tan Kun-Jiang, Feng Na, Li Jing, Chen Lu, Lin Yu-Xuan, Wang Hong-Yang, He Yu-Fei

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) drive recurrence and drug resistance in hepatocellular carcinoma (HCC), but their origin remains controversial: are they tumour-initiating cells or late-stage dedifferentiation products? Direct human single-cell evidence linking bipotent progenitors (BPs) and CSCs has been lacking. METHODS: We integrated single-cell RNA sequencing (scRNA-seq) data from 109 samples (44...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Cell Dedifferentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Liver Neoplasms

Share to Neoplastic Stem Cells

Share to Single-Cell Gene Expression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42337581
DOI: 10.1186/s12967-026-08494-3
PMCID: PMC13307411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Late-stage dedifferentiation and epigenetic memory of cancer stem cells in hepatocellular carcinoma.PMID 42337581Read ↗

Somatic mutation landscape reveals differential variability of cell-of-origin for primary liver cancerSemantic proximity Read ↗

Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma.Semantic proximity Read ↗

Cancer stem cells in hepatocellular carcinoma: Recent progress and perspectiveSemantic proximity Read ↗

Somatic mutation landscape reveals differential variability of cell-of-origin for primary liver cancerSemantic proximity Read ↗

Single‐cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastomaSemantic proximity Read ↗

Stemness Landscape and Its Clinical Implications in Hepatocellular CarcinomaSemantic proximity Read ↗

Multimodal single-cell network analysis uncovers BSG/CD147 as an early biomarker and signaling hub in hepatocellular carcinomaSemantic proximity Read ↗

The Cancer Stem Cell in Hepatocellular CarcinomaSemantic proximity Read ↗

Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastomaSemantic proximity Read ↗

Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and TelomeresSemantic proximity Read ↗

Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progressionSemantic proximity Read ↗

Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.