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The Cancer Stem Cell in Hepatocellular Carcinoma

14 Mar 2020

Abstract excerpt

The recognition of intra-tumoral cellular heterogeneity has given way to the concept of the cancer stem cell (CSC). According to this concept, CSCs are able to self-renew and differentiate into all of the cancer cell lineages present within the tumor, placing the CSC at the top of a hierarchical tree. The observation that these cells-in contrast to bulk tumor cells-are able to exclusively initiate new tumors,...

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PMID: 32183251
DOI: 10.3390/cancers12030684

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